Cancer Predisposition Panel | EasyDNA South Africa

About our test

The Cancer Predisposition Panel test uses Next-Generation Sequencing (NGS) technology to look for mutations in a total of 98 genes associated with 25 hereditary cancers. The analysis will look for those inherited mutations on specific genes which are known to increase a person’s risk of developing a certain type of cancer. It is important to note that inherited mutations can increase your risk of cancer by up to 40 times.

Overall, it is estimated that somewhere between 5-10% of all cancers are hereditary in nature. Early detection is key to successful treatment! The cost of the complete cancer panel test is of R3995 and results are ready in 3-4 weeks from the moment the samples are received at the laboratory.

 

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LifetimeCancerRisk

 

Get tested for 25 different cancers

 

Blood Bone Breast Central Nervous System Cervix
Endocrine Pancreas Endometrium, Uterine
Esophagus Exocrine Pancreas Head and Neck
Kidneys Large Bowel and Rectum Liver Lung and Pleura Endocrine Glands
Myometrium, Uterine Ovaries Peripheral Nervous System Prostate Gland Skin
Small Intestines Soft Tissue Stomach Thyroid Gland Urinary Tract and Bladder

 

Who should consider genetic testing for cancer predisposition?

It is highly recommended that you speak to a doctor or genetic counsellor to establish whether you need this test. There are 3 main criteria which should be met in order for genetic predisposition testing for cancer to be recommended:

 

  • Individuals with a family history of cancer or a medical history that suggests the possibility of a familial type of cancer.
  • Having genetic test results that can be meaningful and reliable. This entails having results that can clearly define whether a specific gene, associated with a certain type of cancer, is actually present.
  • Receiving results that can help inform and guide a person’s medical care.

 

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Sample collection for cancer testing

All we need to establish whether you carry certain genes associated with cancer is a saliva sample which can be collected at home without any medical assistance whatsoever. We will provide our clients with a kit which will contain:

 

  • Collection funnel and tube
  • Preservative Ampoule (2ml.)
  • Identifier label
  • Biohazard specimen bag
  • Consent forms and sample collection instructions
  • Pre-addressed envelope

As soon as the required volume of liquid saliva is collected and the collection tube is stored accordingly, you can send the sample back to us for testing.

Note: Do not eat, drink, chew gum, smoke, floss or brush teeth 30 minutes prior to saliva collection.

Important

Note: Results for this test must be sent directly to a health care professional such as a genetic counsellor or oncologist. These individuals are highly trained and qualified to help you make sense of the results and interpret them. They can provide you with guidelines and valuable information regarding further tests, support you and describe any known factors that may increase or decrease your chances of developing the cancer/s highlighted in your results.

View the full list of genes tested in the Cancer Predisposition Panel test.

Why not consult a genetic counsellor about your results?

Our genetic counsellor is ideal if you have any concerns about your DNA test results. They can understand and interpret all aspects of your DNA test results, helping you maximize your own well-being and that of your relative. Genetic counselling is ideal in cases where you opt for a clinical test or health test but you can also consult our counsellor for any other test including parentage testing, prenatal testing and relationship testing. Genetic counselling is available for an additional fee.

FAQs

 If I don’t have a predisposition to certain cancer, does that mean I will not get it?

This is actually a common misconception. Not having a hereditary gene which predisposes you to a certain type of cancer does not mean you cannot develop that cancer. Many cancers are due to what we call sporadic gene mutations and are not caused by an inherited gene. Lifestyle factors can play an important role in sporadic cancer (for example exposure to the sun, smoking etc).

 Do all blood members in a family inherit a hereditary cancer-predisposing mutation?

No, just because one or more members in a family carry gene mutations, it does not mean that all members of the family will carry that gene.

 Should I test children?

This all depends on the type of cancer we are looking for – in cases of cancers that have a high incidence rate in children, cancer testing could be recommended. Most genetic counsellors, however, would generally advise against cancer testing in people under the age of 18. Individuals should be able to make their own choice as to whether they want to carry out such a test. Again, you need to speak to a genetic counsellor or oncologist to determine whether you or anyone in your family should take this test.

 Do you offer other genetic tests?

Yes, we offer a Genetic Predisposition health test which looks at your likelihood of developing 35 different diseases over the course of your life. The diseases tested fall into various categories including diseases of old age, autoimmune diseases and cardiovascular diseases.

Genetic Predisposition Test
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